【摘要】 目的　探讨蚓激酶的抗脑缺血作用及其可能机制。方法　采用大鼠大脑中动脉闭塞 (MCAO)模型 ,测定缺血 2 4h后大脑梗死面积和脑组织含水量 ,并测定脑组织中总抗氧化能力 (T AOC)、一氧化氮 (NO)含量及一氧化氮合酶 (NOS)活性。结果　各剂量蚓激酶均可显著缩小梗死面积、提高脑组织T AOC(P <0 .0 5或P <0 .0 1) ;蚓激酶3～ 6mg kg可减轻脑水肿 (P <0 .0 5 ) ;6mg kg可降低脑组织NO含量及NOS活性 (P <0 .0 5 )。结论　蚓激酶可缩小梗死面积、减轻脑水肿 ,具有抗脑缺血的作用。其机制可能与提高脑组织T AOC、降低NO含量及NOS活性有关更多还原

【Abstract】 Objective To investigate the anti cerebral ischemia effect and probable mechanisms of Lumbrokinase.Methods The rat model of middle cerebral artery occlusion(MCAO) was established to measure infarction area,water content,nitric oxide(NO)content,nitric oxide synthase(NOS)activity and total antioxidation capability(T AOC) of brain after 24h MCAO.Results The infarction area obviously decreased and T AOC increased in all Lumbrokinase groups ( P <0.05 or P <0.01).The 3～6mg/kg group showed decrease in cerebral water content( P <0.05);Lumbrokinase 6mg/kg could also decrease NO content and NOS activity( P <0.05).Conclusion Lumbrokinase plays a protective role on cerebral ischemia by decreasing infarction area and water content.The decrease of NO content and NOS activity and the increase of T AOC may all contribute to the protective role.更多还原