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IL-2对抗精子抗体大鼠精子顶体酶活力的影响
Effect of IL-2 on the sperm acrosin activity in antisperm antibody positive rat
【摘要】 目的 研究IL 2对抗精子抗体阳性大鼠的精子顶体酶活力的影响。方法 精子顶体酶的活力检测采用BAEE ADH联合法。结果 抗精子抗体 (AsAb)阳性大鼠精子顶体酶的活性显著降低 ;IL 2可显著降低AsAb阳性大鼠精子顶体酶的活性 (P <0 .0 0 1) ;AsAb阳性精子的SOD酶活性降低 (P <0 .0 0 1) ;IL 2可使精子中的SOD酶活性降低 (P <0 .0 0 1) ,增强了氧自由基的产生。结论 IL 2对精子顶体酶活性有显著影响。
【Abstract】 Objective To investigate the effect of IL 2 on the sperm acrosin activity in positive antisperm antibody rat.Methods The sperm acrosin activity was detected by BAEE/ADH method.Results IL 2 decreased the sperm acrosin activity in positive rat ( P <0.001).The results also indicated that IL 2 significantly decreased the SOD activity ( P <0.001) and increased oxygen free radicals of sperms.Conclusion IL 2 could influence the sperm acrosin activity.
【关键词】 IL-2;
顶体酶活性;
抗精子抗体;
精子;
大鼠;
【Key words】 IL 2; acrosin activity; antisperm antibody; spermatozoa; rat;
【Key words】 IL 2; acrosin activity; antisperm antibody; spermatozoa; rat;
- 【文献出处】 哈尔滨医科大学学报 ,Journal of Harbin Medical University , 编辑部邮箱 ,2003年01期
- 【分类号】R321.1
- 【被引频次】6
- 【下载频次】50