【摘要】 目的 :评价非那雄胺对大鼠前列腺腺上皮及微血管的影响。方法 :①按 4 0mg/kg·d喂饲雄性SD大鼠非那雄胺 7天 (B组 ) ,14天 (C组 )。②HE染色观察前列腺腺上皮及采用墨汁灌注染色大鼠前列腺微血管的改变。结果 :①B组、C组高柱状上皮及内折乳头逐渐减少 ,扁平或立方状上皮逐渐增多。②A组 (对照组 ) ,B组 ,C组的微血管密度分别为 6 8 2± 12 8,4 4 2± 7 7和 30 6± 6 7;B组 ,C组的微血管密度较A组分别减少35 2 %及 5 6 %。结论 :非那雄胺可抑制大鼠前列腺腺上皮的生长及微血管生成更多还原

【Abstract】 Objective:To investigate the influences of finasteride on the epithelium and capillary in the ventral prostate of rat.Method:1 Male SD rats were taken finasteride 40md/kg·d for 7 days (B group) and 14 days(C group)respectively.2 The changes of the epithelium and the capillary infused with Chinese ink were observed with the use of HE staining.Results:1 High cylindrical epithelium and papillary became less and less,pavement epithelium or cubical epithelium became more and more step by step in group B and group C.2 MVD value was 68 2±12 8,(group A,control group);44 2±7 7(group B),and 30 6±6 7 (group C),and the group B was decreased 35 2% than group A,and group C was decreased 56% than group A.Conclusion:Finasteride could epithelium growth and angiogenesis of capillary in the ventral prostate of rat.更多还原