【作者】
姚俊；
刘义；
刘建本；
周琴；
秦霞；
刘鹏；
董家新；
屈松生；
喻子牛；
【Author】
YAO, Jun a,c LIU, Yi b LIU, Jian Ben c ZHOU, Qin a Qin, Xia b LIU, Peng b DONG, Jia Xin b QU, Song Sheng b YU, Zi Niu , a a Key Laboratory of Agricultural Microbiology of Chinese Agriculture Ministry, Huazhong Agricultural University, Wuhan, Hubei 430070, China b Department of Chemistry, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China c College of Life Sciences and Chemistry, Jishou University, Jishou, Hunan 416000, China
【机构】
Key Laboratory of Agricultural Microbiology of Chinese Agriculture Ministry, Huazhong Agricultural University,Department of Chemistry,College of Chemistry and Molecular Sciences,Wuhan University,College of Life Sciences and Chemistry, Jishou University,Key Laboratory of Agricultural Microbiology of Chinese Agriculture Ministry, Huazhong Agricultural University,Department of Chemistry,College of Chemistry and Molecular Sciences,Wuhan University,Department of Chemistry,College of Chemistry and Molecular Sciences,Wuhan University,Department of Chemistry,College of Chemistry and Molecular Sciences,Wuhan University,Department of Chemistry,College of Chemistry and Molecular Sciences,Wuhan University,Key Laboratory of Agricultural Microbiology of Chinese Agriculture Ministry, Huazhong Agricultural University Wuhan, Hubei430070, China；
College of Life Sciences and Chemistry, Jishou UniversityJishou, Hunan 416000, China,Wuhan, Hubei 430072,China ,Jishou, Hunan 416000, China,Wuhan, Hubei430070, China,Wuhan, Hubei 430072,China ,Wuhan, Hubei 430072,China ,Wuhan, Hubei 430072,China ,Wuhan, Hubei 430072,China ,Wuhan, Hubei430070, China；
【Abstract】 Microcalorimetry was used to study the inhibitory or antibiotic action of six kinds of the model compounds of purple acid phosphatases on a strain of Aerobacter aerogenes . Difference in their capacities to inhibit the metabolism of this bacterium was observed. The extent and duration of the inhibitory effect on the metabolism as judged from the growth rate constant, k , and the half inhibitory concentration, IC 50 , varied with the different drugs. The rate constant k of A. aerogenes (in the log phase) in the presence of the compounds decreased with the increasing of concentrations. The experimental results reveal that the order of the antibiotic activity of the compounds is: LD 1>LD 2>LD 3>XF 1>LD 4～LD 5.更多还原
【基金】 theNationalNaturalScienceFoundationofChina (Nos .3 0 170 0 102 9973 0 3 0 ) ;theTeachingandResearchAwardProgramforOutstandingYoungProfessorsinHighEducationInstitutes MinistryofEducation China ( 2 0 0 1)
