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SmI2-Mediated Addition Reaction of α-Halomethylsulfones to Carbonyl Compounds.A Convenient Synthesis of β-Hydroxysulfones
SmI2-Mediated Addition Reaction of α-Halomethylsulfones to Car-bonyl Compounds. A Convenient Synthesis of β-Hydroxysulfones
【摘要】 <正> Due to the chemoselective dehalogenation by SmI2, the additionof α-halomethylsulfones to carbonyl compounds afforded β-hy-droxysulfones. Those reactions with α-bromomethylsulfonesgave the products in moderate to good yields. The SmI2-mediat-ed addition of gem-dihalomethylsulfones to ketones also afford-ed α-halo-β-hydroxysulfones in moderate yields.
【Abstract】 Due to the chemoselective dehalogenation by SmI2, the addition of α-halomethylsulfones to carbonyl compounds afforded β-hy-droxysulfones. Those reactions with α-bromomethylsulfones gave the products in moderate to good yields. The SmI2-mediat-ed addition of gem-dihalomethylsulfones to ketones also afforded α-halo-β-hydroxysulfones in moderate yields.
【关键词】 SmI2-mediated addition；
synthesis；
β-hydroxysul-fones；
α-halo-β-hydroxysulfones；
【Key words】 SmI2-mediated addition； synthesis； β-hydroxysul-fones； α-halo-β-hydroxysulfones；
【Key words】 SmI2-mediated addition； synthesis； β-hydroxysul-fones； α-halo-β-hydroxysulfones；
【基金】 Project supported by the National Natural Science Foundation of China(No.20272050).
- 【文献出处】 Chinese Journal of Chemistry ,中国化学(英文版) , 编辑部邮箱 ,2003年07期
- 【分类号】O621
- 【下载频次】6