【摘要】 <正> An efficient lipase-catalyzed enantioselective hydrolysis of bu-tyryloxyalkanephosphonates in water-equilibrated diisopropylether was developed. The relationship between the substrates’structure and the reactivity, as well as the enantioselectivity ofthis enzymatic transformation was studied. The catalytic pref-erence of crude Candida rugosa lipase toward such moleculeswas assigned according to modified Mosher’s method and X-ray crystallographic analysis. Optically pure 2-hydroxy-2-arylethanephosphonates, 3-hydroxy-3-phenylpropanephosphon-ate, and 3, 3, 3-trifluoro-2-hydroxypropanephosphonates wereconveniently prepared in this manner.更多还原

【Abstract】 An efficient lipase-catalyzed enantioselective hydrolysis of bu-tyryloxyalkanephosphonates in water-equilibrated diisopropyl ether was developed. The relationship between the substrates’ structure and the reactivity, as well as the enantioselectivity of this enzymatic transformation was studied. The catalytic preference of crude Candida rugosa lipase toward such molecules was assigned according to modified Mosher’s method and X-ray crystallographic analysis. Optically pure 2-hydroxy-2-arylethanephosphonates, 3-hydroxy-3-phenylpropanephosphon-ate, and 3,3,3-trifluoro-2-hydroxypropanephosphonates were conveniently prepared in this manner.更多还原