【摘要】 目的　研究 N- [2 - (胆固醇氧羰基氨基 )乙基 ]甲氨酰甲基化甘露聚糖 (chol- AECM- mannan)合成的途径。方法　以甘露聚糖为原料 ,经过羧甲基化、甲氨酰化和缩合反应合成一种被胆固醇部分修饰的多聚糖化合物 ,即 chol- AECM- mannan。结果　经过红外光谱 (IR)和氢核磁共振谱 (1 HNMR)检测证实了产物为胆固醇部分修饰的多聚糖化合物 ,(chol- AECM- Mannan) ,而且甘露聚糖部分与胆固醇部分氢原子比例为 10 0∶ 5 ,即每一百个甘露糖单糖单位接有 1.1个胆固醇 ,产率为 2 4 %。结论　此方法是合成 chol- AECM- m annan的一个有效途径更多还原

【Abstract】 Objective To study the synthesis of chol AECM mannan. Methods Using mannan as the main material, we synthesized a compound with polysaccharides partially modified by cholesterol (namely chol AECM mannan) through carboxymethylating,carbamoylating and condensation reaction. Results The product was confirmed by IR spectrum and 1H nuclear magnetic resonance ( 1HNMR). The proton integral ratio of mannan and cholesterol is 100∶5, that is to say, the numbers of the substituted cholesterol per 100 mannose units are 1.1.The production rate is 24%. Conclusion The method is a effective pathway in term of synthesizing chol AECM mannan.更多还原