【摘要】 为了合成具有较高骨摄取和较低血液、肌肉、脾、肺摄取的放疗药物,以用于骨癌和骨转移癌治疗,合成了4种117Snm 胺基膦酸类配合物,并对其在生物体内的分布进行了比较。研究结果表明,117Snm TTHMP可望成为骨肿瘤治疗药物。更多还原

【Abstract】 The preparation and in vivo biodistribution in m ice of several 117 Sn m labelled compounds are studied. The results indicate that the favourable half-life and decay characteristics of 117 Sn m in various stannic compounds, especially stannic-TTHMP. It appears to be the best overall bone localizing agent with very low blood, muscle, kidney, or liver uptake and the binding of 117 Sn m-TTHMP to bone is higher than that of 117 Sn m-DTPA. This makes it potentially useful as an agent for skeletal scintigraphy and radiotherapy of bone tumors.更多还原