节点文献

胃腺癌组织中细胞胀亡与TSP-1检测

Detection of oncosis and TSP-1 in gastric adenocarcinoma

推荐 CAJ下载
PDF下载
不支持迅雷等下载工具，请取消加速工具后下载。

【作者】僧靖静；赵高峰；王公平；杨振；李向阳；卫利民；张斌；张谢夫；僧国珍；李惠东；陈奎生；高冬玲；张云汉；

【Author】 SENG Jingjing 1) ,ZHAO Gaofeng 1) ,WANG Gongping 1) ,YANG Zhen 1) ,LI Xiangyang 1) , WEI Limin 1) ,ZHANG Bin 1) ,ZHANG Xiefu 1) ,SENG Guozhen 1) ,LI Huidong 1) ,CHEN Kuisheng 2) ,GAO Dongling 2) ,ZHANG Yunhan 2) 1)Department of Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 2)Department of Pathology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052

【机构】郑州大学第一附属医院外科；郑州大学第一附属医院病理科；郑州大学第一附属医院病理科郑州450052；郑州450052；郑州450052；

【摘要】目的 :检测胃腺癌组织中胀亡与TSP - 1。方法 :采用免疫组化SP法检测 4 5例胃腺癌组织中TSP - 1的表达 ,并与正常对照组进行比较 ,利用透射电镜技术观察其中肿瘤细胞的胀亡情况。结果 :①TSP - 1在胃腺癌组织中阳性表达率为 4 6 .6 7% ,在正常胃粘膜中未见表达 ,差异有显著性 ;②胃腺癌组织中发现有不同时期的胀亡细胞 ,胀亡指数 (OI)在TSP - 1阳性组、阴性组分别为 (2 .78± 0 .96 )、(1 .0 5± 0 .34) ,2组间差异有统计学意义 (P <0 .0 5 ) ;③OI、TSP - 1的阳性表达率在有淋巴结转移组高于无淋巴结转移组 (P <0 .0 5 ) ;④TSP - 1及OI与胃癌的大体分型、组织学类型、肿瘤大小、肿瘤部位及患者性别、年龄无关。结论 :胃腺癌组织中TSP - 1可抑制肿瘤血管形成 ,从而抑制肿瘤的侵袭转移 ,加速胀亡的形成更多还原

【Abstract】 Aim: To investigate the correlation between oncosis and TSP-1 in gastric adenocarcinoma. Methods: The expression of TSP-1 was detected by immunohistochemical method, and the oncosis was observed by utilizing transmission electron microscope in 45 cases of gastric adenocarcinoma tissues and 10 cases of normal gastric mucosa. Results:The positive rate of TSP-1 in gastric adenocarcinoma was 46.67% and there was no TSP-1 expression in normal gastric mucosa. Oncosis index(OI) in the group with TSP-1 positive expression and the group with TSP-1 negative expression were 2.78±0.96 and 1.05±0.34, respectively. The difference between the 2 groups was significant. OI and the expression of TSP-1 in cases with lymph node metastasis were higher than those without. The expression of TSP-1 and OI had no correlation with histological stages, tumor size and location, age and sex. Conclusion: TSP-1 can hold back tumor invasion, and metastasis and accelerate cell oncosis through inhibiting angiogenesis in gastric adenocarcinoma.更多还原

【关键词】胃肿瘤；腺癌； TSP-1；胀亡；
【Key words】 gastric neoplasm； adenocarcinoma； TSP-1； oncosis；

【基金】河南省杰出青年科学基金资助项目　 0 3 12 0 0 2 3 0 0

【文献出处】郑州大学学报(医学版) ,Journal of Zhengzhou University(Science Medical) , 编辑部邮箱 ,2003年06期

【分类号】R735.2
【被引频次】1
【下载频次】88

知网节下载

节点文献中：

本文链接的文献网络图示:

本文的引文网络

节点文献