【摘要】 目的　探讨大鼠失神经后骨密度变化的可能原因 ,以及NGF注射、电刺激和被动运动等治疗的应用价值 ,并为临床预防神经源性骨质疏松的治疗提供实验依据。方法　切断SD雄性大鼠坐骨神经和股神经 ,造成失神经支配大鼠模型 ,利用NOR LAND、XR 36型双能骨密度检测仪进行骨量测定。结果　大鼠失神经支配可引起骨密度的改变 ,通过NGF注射、电刺激和被动运动等治疗可减缓失神经大鼠的骨量下降 ,而失神经肢体的固定则加重了骨量的降低。结论　通过大鼠失神经后的骨密度变化 ,说明股骨密度在失神经支配后受多种因素的调控 ,其中力学因素是其首要和主要因素 ,同时大鼠失神经支配后 ,促进神经功能的重建以及维持神经再支配的生物学环境的稳定将有利于防止骨量的下降和骨质疏松的发生。更多还原

【Abstract】 Objective To provide experimental evidences for the therapy of neuropathic osteoporosis,we discussed the causes of the changing in bone mass of denervated rats and the application of Nerve Growth Factor(NGF)injection,electrical stimulation,and passive movement.Methods To make the denervated rats model,we performed neurotomy on sciatic nerve and femoral nerve of male Sprague-Dawley(SD)rats.The density of femoral bone was measured by dual energy absorptiometry(NORLAND·XR-36,U.S).Results Bone mass decreased after the rats were denervated.NGF injection,electrical stimulation,and passive movement slowed the decreasing of bone mass,while the immobilization of denervated rats increased the mass losing.Conclusion The results indicate that the force factor plays a big role in the several factors that affect the bone mass losing.Reinnervation and maintenance of nerve function may benefit the prevention of bone mass losing and osteoporosis.更多还原