【摘要】 目的　评估两种浓度A型肉毒毒素治疗偏侧面肌痉挛的疗效 ,并探讨减少其并发症的方法。方法　将 60例患者随机分为A、B两组 ,A组对上、下睑及面肌进行多点注射 ,A型肉毒毒素 (BTA)浓度为 5 0u/0 1ml,B组注射浓度为 2 2 5u/0 1ml。比较两组间疗效、副作用发生情况。结果　两组治疗疗效相似 ,总有效率为 10 0 % ,A组症状完全缓解 18例 (60 % ) ,明显缓解 6例(2 0 % ) ,部分缓解 6例 (2 0 % ) ,总显效率 80 % ;B组完全缓解 16例 (5 3 3 % ) ,明显缓解 6例 (2 0 % ) ,部分缓解 8例 (2 6 7% ) ,总显效率73 3 %。两组均无过敏和全身中毒反应 ,但A组出现上睑下垂、眼睑闭合不全、视物模糊等不良反应例数明显增多 ,差异显著 ,P <0 0 5。结论　BTA治疗面肌痉挛以小剂量为宜。A型肉毒毒素治疗偏侧面肌痉挛安全有效 ,简单易行 ,副作用少而轻微、短暂 ,为治疗面肌痉挛的首选方法更多还原

【Abstract】 Objective To study the effect of botulinum toxin A to treat hemifacial spasm with two kinds density,and to investigate a way with which to reduce the complication of them.Methods The patients were randomly divided into group A or into group B.The patients of group A were injected with Botulinum toxin A(BTA) in blepharoes and hemiface,the density was 5.0u/0.1ml. The density for group B was 2.25u/0.1ml. To compare the effect and side effect between two groups.Results The effect of two groups were approximate, the total efficiency rate was 100%. In group A,18 parients′s symptom were relieved completely(60%),6 patients′s symptom were relieved obviously(20%),and 6 patients′s symptom were relieved partially(20%),the obvious efficiency rate was 80%.In group B,16 patients′s symptom were relieved completely (53.3%),6 patients′s symptom were relievd obviously(20%),and 8 patients′s symptom were relieved partially(26.7%),the obvious efficiency rate was 73.3%.There were no systemic adverse and allergic reactions.But in group A,there were some instances with side reactions more than group B,suth as up blepharo droop,and etc,and the difference was marked,P<0 05. Conclusions The effect of botulinum toxin A to treat hemifacial spasm with little dose was benifit.It was a safe, simple, effective method,the side effect was a little,venial,transient.It is a first select way to treat hemifacial spasm更多还原