【摘要】 目的　观察Ki6 7抗原在喉癌的表达及与转移、预后的关系。方法　用S -P免疫组化法测定 4 5例喉癌手术标本蜡块的常规病理切片中Ki6 7抗原的表达 ,并取 9例正常喉黏膜组织和 7例喉良性病变作对照。结果　Ki6 7抗原在喉癌组织的表达远高于正常喉黏膜组织、喉良性病变中的表达 ,有明显差异 (P <0 0 5 ;P<0 0 5 )。在有临床转移者与无临床转移者之间及死亡与未死亡病例间无明显差异 (P >0 2 5 ;P >0 2 5 )。结论　Ki6 7抗原表达的阳性率对诊断喉部病变的性质有较高的实用价值 ,但尚不能判断喉癌的转移和预后更多还原

【Abstract】 Objective To observe the expression of Ki-67 antigen and the relation between Ki-67 antigen and the metastasis and prognosis of laryngeal carcinoma. Methods The expression of Ki-67 antigen of 45 cases laryngocarcinoma in pathology section was detected with S-P immunohistochemical method and 9 normal membrane of throat specimen and 7 benign lesions were taken as control. Results The expression of Ki-67 in laryngocarcinoma was far more than those in normal membrane and benign lesion of throat with significant difference (P<0.05). While neither between metastasis and no metastasis cases nor between death and survival cases had such difference (P>0.25). Conclusion The positive rate of Ki-67 antigen’s expression might have great value in diagnosis of laryngocarcinoma. But it seems no use to judge the metastasis and the prognosis of laryngocarcinoma.更多还原