【摘要】 目的探讨氧化型染发剂潜在的致癌危险性。方法以NIH3T3细胞株建立体外细胞转化系统,以氧化型染发剂的主要成分对苯二胺与双氧水混合后的氧化产物作为受试物,观察其对细胞的转化作用。结果在试验剂量(0.8、0.4、0.2、0.1μg/ml)范围内,对苯二胺氧化产物均能诱导NIH3T3细胞发生转化,并呈现良好的剂量一反应关系。转化细胞能够在软琼脂中生长,并具有恶性特征。结论对苯二胺氧化产物具有诱导NIH3T3细胞恶性转化的作用,提示氧化型染发剂对机体有潜在的致癌危险性。更多还原

【Abstract】 Objective To study the potential carcinogenicity of oxidized hair dyes. Methods NIH3T3 cells were used to develop a cell-transforming system in vitro. The main oxidized products of paraphenylendiamine (PPD), as the test compound, was formed by oxidization of hydrogen peroxide. Results The results showed that the oxidized products of PPD could induce transformation of NIH3T3 cells within the experimental dose range (0.8、0.4、0.2、0.1 μg/ml), and with an obvious dose-response relationship. Transformed cells exhibited malignant characteristic by growing in colonies on semisolid agar. Conclusion It was possible that malignant transformation of NIH3T3 cells could be induced by oxidized products of PPD and oxidized hair-dyes might have potential carcinogenicity to humans.更多还原