【摘要】 为探索锝膦混配配合物的制备方法,寻找新的心肌显像剂,合成了一个新的N3S配体(MVNE)和3个膦配体。通过交换反应在室温下制备了放化纯>95%的99Tcm-MVNE, 然后分别与3种膦配体混配得到放化纯>90%的99Tcm-MVNE-膦混配配合物。小鼠体内的生物分布研究表明,该类混配配合物有较高的的心肌摄取,血液清除也较快。更多还原

【Abstract】 To explore the synthetic methods of phosphine mixed complexes of technetium-99m and look for new heart imaging agents, one N3S ligand (MVNE) and three phosphine ligands were synthesized. 99Tcm-MVNE prepared at room temparature through ligand-exchange reaction reacts with the three phosphine ligands respectively to obtain three mixed complexes of 99Tcm-MVNE-phosphine. The biodistribution studies in mice indicate that these complexes exhibit pretty high myocardial uptake and high blood clearance rate.更多还原