【摘要】 采用体外动态凝血时间实验评价了ZnO纳米材料的抗凝血性能. 纳米材料的平均粒度在10~30 nm. 实验分为对照组(抗凝全血1 ml)、无纳米组(抗凝全血1 ml,包括搅拌血浆0.4 ml)、ZnO纳米材料组(抗凝全血1 ml,包括搅拌血浆0.4 ml,加入ZnO纳米材料1 mg)和Fe纳米材料组(抗凝全血1 ml,包括搅拌血浆0.4 ml,加入Fe纳米材料1 mg). 每组样品分别在5, 15, 30及45 min测定光密度值,计算结果表明,ZnO纳米材料的抗凝血率在45 min时仍保持在70%,而对照组和Fe纳米材料组的抗凝血率在15 min时已降至30%. 实验表明ZnO纳米材料具有良好的抗凝血作用.更多还原

【Abstract】 Evaluation of antithrombogenicity of ZnO nanoparticles was carried out based on the measurements of in vitro kinetic clotting time. The average size of the ZnO nanoparticles was 10~30 nm. The research was divided into the control group (1 ml of whole blood), the non-nanoparticles group (1 ml of whole blood, including 0.4 ml of the stirred plasma), the ZnO group (1 ml of whole blood, including 0.4 ml of the stirred plasma and 1 mg of ZnO nanoparticles) and the Fe group (1 ml of whole blood, including 0.4 ml of the stirred plasma and 1 mg of Fe nanoparticles). Measurements of clotting time of every group were carried out at 5, 15, 30 and 45 min. The calculated results revealed that the thromboresistant radio was remained at 70% in 45 min in the ZnO nanoparticles group, while the radio dropped to 30% in 15 min in the control group, the non-nanoparticles group and the Fe group. The results predict that the ZnO nanoparticles have excellent thromboresistant property.更多还原