【摘要】 目的　观察下肢骨折卧床患者与非骨折患者血中纤维蛋白原水平 ,并了解其与近期下肢静脉血栓形成之间的关系如何。方法　选择非暴力下肢骨折入院及因非骨折因素入院患者 ,入院时检测血中纤维蛋白原水平 ,并观察在住院期间是否会发生下肢静脉血栓形成。结果　骨折组纤维蛋白原水平及血栓发生率均高于对照组 ,然而在骨折卧床这同一条件下 ,高纤维蛋白原水平组及高龄组中血栓形成发生率不高于同组相对低纤维蛋白原水平及低龄组。结论　只要因下肢骨折卧床的患者 ,不论年龄高低及血中纤维蛋白原水平高低 ,均应给予预防血栓治疗更多还原

【Abstract】 Objective To study the level of fibrinogen in blood of the patients with or without low limb fracture and study the relationship between the fibrinogenic level and deep venous thrombosis.Methods The fibrinogenic level in blood of 266 patients from 1999 to 2001 admission because of acute low limb fracture were tested within 24 hours after trauma,the other 111 patients without fracture were the control group.All the patients were older than 45 years without malignity tumor and accepting no drug that might act on platelet and fibrinogen.They had to stay in the hospital for 14 days at least,if the patient had obvious edema in one limb and the difference between two limbs in the symmetry part was more than 3cm,they would be judged as deep venous thrombosis.Results The level of fibrinogen in the blood of fracture patients was higher than that of the patients without fracture,the ratio of venous thrombosis in the fracture patients was also higher than that of the control group,but if the patient had low limb fracture,neither the level of fibrinogen nor the age increase the risk of venous thrombosis.Conclusion The patient who has low limb fracture should be treated with prophylactic thrombosis drug after trauma regardless the age and the fibrinogenic level in the blood.更多还原