【摘要】 目的探讨麝香鼻康灵的主要药效学。方法采用大鼠离体后肢血管阻力、二甲苯致小鼠耳肿胀及致敏豚鼠回肠平滑肌过敏性收缩试验。结果麝香鼻康灵 17、5 1、170mg/kg可提高大鼠离体后肢血管阻力 (P <0 .0 5和 0 .0 1) ;麝香鼻康灵 30mg/kg明显减轻二甲苯所致小鼠耳廓炎症 (P <0 .0 5 ) ;麝香鼻康灵 0 .85、2 .5 5、8.5mg/kg显著抑制致敏豚鼠回肠肌的过敏性收缩 (P <0 .0 1)。结论麝香鼻康灵具有收缩血管、抗炎和抗变态反应的作用。更多还原

【Abstract】 ObjectiveTo observe the main pharmacodyn amics of Shexiangbikangling (SXBKL).MethodsIsolated blood vessel, ear edema and Schulty Dale reaction were used.ResultsSXBKL dose dependently increased vascular resistance (P< 0.05 ,P< 0.01 ), SXBKL 30 mg/kg reduced ear edema degree (P< 0.05 ),and inhibited allergic contraction of guinea pig ileum (P< 0.01 ).ConclusionSXBKL may produce therapeutic effect on stuffy nose through vascular contraction, anti inflammation and anti allergy.更多还原