【摘要】 目的 :研究牛磺酸对肝纤维化形成的影响。方法 :采用四氯化碳 (CCl4 )诱导大鼠肝纤维化模型 ,分别采用高剂量及低剂量牛磺酸干预 ,测定血清转化生长因子 β1 (TGF β1 )、肿瘤坏死因子α(TNFα)、透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ )。结果 :牛磺酸治疗组明显抑制HA、PCⅢ、TGF β1 、TNFα的水平。结论 :牛磺酸具有抗实验性大鼠肝纤维化作用 ,其机制可能与抑制TGF β1 、TNFα的水平有关。更多还原

【Abstract】 Objective:To investigate the effect of taurine on the development of hepatic fibrosis.Methods:The model rats livers were made to be fibrotic by carbon tetrachloride(CCl 4).Taurine was administrated at the vast dose group and lower dose group.The variety of hyaluronic acid(HA),procollagen typeⅢ(PCⅢ),transforming growth factor β 1(TGF β 1) and tumor necrosis factor α (TNF α) in the rats serum were observed.Results:In the taurine treating group,the level of HA,PCⅢ,TGF β 1 and TNF α dropped remarkably.Conclusion:Taurine can prevent the progress of hepatic fibrosis in rats,which may associate with that taurine plays a role in inhibiting the level of TGF β 1.更多还原