【摘要】 目的 :探讨老年男性骨密度 (BMD)与胰岛素样生长因子 - I(IGF- I)及性激素水平的关系。方法 :采用双能 X线骨密度仪测定老年男性骨密度 ,将研究对象分为骨质疏松组 (OP) 33例及非骨质疏松组 (NOP) 30例 ,分别测定他们的血 IGF- I及雌二醇 (E2 )、血睾酮 (T)水平 ,并将结果进行统计分析。结果 :老年男性 IGF- I、T水平在骨质疏松组明显降低 ,与非骨质疏松组相比差异有统计学意义 (P <0 .0 1)。IGF- I与 L2 、L3椎体 BMD呈正相关 (P <0 .0 5 ) ;T与 L2～ 4 椎体、Ward’s区骨密度呈正相关 (P <0 .0 5 ) ;IGF- I与 T呈正相关 (P <0 .0 5 )。结论 :老年男性骨质疏松的发生与 IGF- I、T水平下降有关。更多还原

【Abstract】 Objective:To investigate the relationship of the bone mineral density and insulin-like growth factor-Ⅰand sex hormone in aged men.Methods:forearm bone mineral densities of 63 aged men were measured by dual energy X-ray absorptiometry(DEXA). The subjects were divided into two groups,the OP group(n=33)ne-OP group (n=30)ition, the level of insulin-like growth factor-Ⅰ(IGF-Ⅰ), estradiol(E 2), testosterone(T) were assayed.Result:The level of IGF-Ⅰand T were lower significantly than those in NOP group.The levels of IGF-Ⅰ was positively correlated with BMD of L 2,L 3(P<0.05);the level of T was positively correlated with BMD of L 2,L 3,L 4 and ward’s area(P<0.05); and IGF-Ⅰwas positively correlated with T.Conclusion:The development of osteoporosis was correlated with the decrease of IGF-Ⅰand T in aged men.更多还原