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老年男性骨质疏松与IGF-I及性激素水平的相关研究

THE STUDY OF THE RELATIONSHIP BETWEEN IGF-Ⅰ AND SEX HORMOME IN AGED MEN

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【作者】 陈露文杨瑞平李素兰甘晓健陈友华黄莹唐萍蔡保芳

【Author】 Chen Luwen,Yang Ruiping,Li Sulan,et al.(The People Hosiptal of Guangxi Zhuang Autonomous Region, Nanning 530021 China)

【机构】 广西壮族自治区人民医院内分泌科广西壮族自治区人民医院内分泌科 南宁530021南宁530021南宁530021

【摘要】 目的 :探讨老年男性骨密度 (BMD)与胰岛素样生长因子 - I(IGF- I)及性激素水平的关系。方法 :采用双能 X线骨密度仪测定老年男性骨密度 ,将研究对象分为骨质疏松组 (OP) 33例及非骨质疏松组 (NOP) 30例 ,分别测定他们的血 IGF- I及雌二醇 (E2 )、血睾酮 (T)水平 ,并将结果进行统计分析。结果 :老年男性 IGF- I、T水平在骨质疏松组明显降低 ,与非骨质疏松组相比差异有统计学意义 (P <0 .0 1)。IGF- I与 L2 、L3椎体 BMD呈正相关 (P <0 .0 5 ) ;T与 L2~ 4 椎体、Ward’s区骨密度呈正相关 (P <0 .0 5 ) ;IGF- I与 T呈正相关 (P <0 .0 5 )。结论 :老年男性骨质疏松的发生与 IGF- I、T水平下降有关。

【Abstract】 Objective:To investigate the relationship of the bone mineral density and insulin-like growth factor-Ⅰand sex hormone in aged men.Methods:forearm bone mineral densities of 63 aged men were measured by dual energy X-ray absorptiometry(DEXA). The subjects were divided into two groups,the OP group(n=33)ne-OP group (n=30)ition, the level of insulin-like growth factor-Ⅰ(IGF-Ⅰ), estradiol(E 2), testosterone(T) were assayed.Result:The level of IGF-Ⅰand T were lower significantly than those in NOP group.The levels of IGF-Ⅰ was positively correlated with BMD of L 2,L 3(P<0.05);the level of T was positively correlated with BMD of L 2,L 3,L 4 and ward’s area(P<0.05); and IGF-Ⅰwas positively correlated with T.Conclusion:The development of osteoporosis was correlated with the decrease of IGF-Ⅰand T in aged men.

【基金】 广西科技厅基金资助项目 :桂科攻 0 1610 13
  • 【文献出处】 广西医科大学学报 ,Journal of Guangxi Medical University , 编辑部邮箱 ,2003年05期
  • 【分类号】R58
  • 【被引频次】7
  • 【下载频次】74
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