【摘要】 目的:采用肱动脉血流介导的血管扩张(FMD)评价氯沙坦对高血压患者血管内皮功能的影响。方法:测定20例轻、中度原发性高血压患者肱动脉基础FMD及最大血流速度(Vmax)。予以口服氯沙坦50mg/d,8周后复查FMD及Vmax,同时观测血压变化。结果:口服氯沙坦8周后肱动脉血管内径无明显变化,而FMD由(4.64±3.72)％增大到(7.68±16.12)％,加压前Vmax、加压后Vmax较服药前增大,有统计学意义(P<0.05),且FMD的增大与血压降低并无相关性。结论:肱动脉FMD可以作为评价内皮依赖性血管扩张的有效方法;口服氯沙坦8周可以改善高血压患者血管内皮依赖性舒张功能,且这种改善与血压降低不相关。更多还原

【Abstract】 Objective: To investigate the effect of losartan on endothelial function in patients with essential hypertension by using flow-mediated vasodilation(FMD) of brachial artery. Methods: We tested the basic FMD and maximum velocity(Vmax) of brachial artery in 20 patients with essential hypertension. After giving the patients 50mg losartan per day for 8 weeks, the FMD and Vmax was tested again. The blood pressure (BP) was measured simultaneously. Results: After the treatment there were no significant changes of brachial artery initial diameter while FMD increased significantly (4. 64% ± 3. 72% vs 7. 68% ± 6. 12% , P = 0.024) and the change was independent of BP decreasing. The Vmax was also increased significantly. Conclusions: The brachial FMD can be regarded as a useful method to evaluate endothelial-dependent vasodilative function. Flow-mediated brachial artery dilation would be improved afer taking losartan 50mg/d for 8 weeks, and this is independent of BP decreasing.更多还原