【摘要】 目的　了解我院产超广谱 β 内酰胺酶菌株的耐药情况。 方法　用纸片扩散法检测了 10 0株产超广谱β 内酰胺酶的大肠埃希菌和肺炎克雷伯菌对 16种抗生素的耐药性。 结果　 6 6株产ESBLs的大肠埃希菌对 16种抗生素的敏感性排在前三位的是 :亚胺培南 (10 0 % ) ,头孢哌酮 /舒巴坦 (10 0 % ) ,哌拉西林 /他唑巴坦 (94 .1% ) ;34株产ESBLs肺炎克雷伯菌对 16种抗生素的敏感性排在前三位的是 :亚胺培南 (97.0 % ) ,哌拉西林 /他唑巴坦(84 .6 % ) ,头孢吡肟 (73.7% )。结论　治疗产ESBLs大肠埃希菌引起的感染的首选药物为亚胺培南和头孢哌酮 /舒巴坦 ,其次为哌拉西林 /他唑巴坦 ;治疗产ESBLs肺炎克雷伯菌引起的感染的首选药物是亚胺培南 ,其次是哌拉西林 /他唑巴坦 ;产ESBLs肺炎克雷伯菌对常见药物的敏感性普遍低于产ESBLs的大肠埃希菌更多还原

【Abstract】 Objective To investigate the antibiotic resistance of clinical isolates that produced extended spectrum β lactamases(ESBLs) in our hospital. Methods Antibiotic susceptibilities of 100 ESBL producing strains of Escherichia coli and Klebsiella pneumoniae were determined by Kirby Bauer test. Results The first three susceptible antimicrobial drugs for the 66 strains of Escherichia coli were imipenem ( 100% ), cefoperazone/sulbactam ( 100% ) and piperacillin/tazobactam ( 94.1% ); the first three susceptible antimicrobial durgs for 34 strains of Klebsiella pneumoniae were imipenem ( 97.0% ), piperacillin/tazobactam ( 84.6% ) and cefepime ( 73.7% ). Conclusion Imipenem and cefoperazone/sulbactam are the best drug for treatment of ESBL producing Escherichia coli, the next is piperacillin/tazobactam. As for Klebsiella pneumoniae, imipenem is the best one, the next is piperacillin/tazobactam. The antibiotic susceptibility of Klebsiella pneumoniae is generally lower than that of Escherichia coli.更多还原