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诺模图法预测口服给药的吸收速率常数

Development of A Nomogram that Estimate The Absorption Rate Coefficient after Oral Administration

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【作者】 李玉红赵欣嵇晴徐建国孙瑞元

【Author】 LIYu-hong ZHAO Xin JI Qing XU Jian-guo SUN Rui-yuan(School of Life Science, Nanjing University, Nanjing 210093) (Department of Anesthesiology, Jinling Hospital, Nanjing 210002) (Institute of Clinical Pharmacology, Yijishan Hospital, Wannan Medical College, Wuhu 241001)

【机构】 南京大学生命科学院金陵医院麻醉科皖南医学院弋矶山医院临床药物研究所 江苏 南京 210093金陵医院麻醉科江苏 南京 210002江苏 南京 210093安徽 芜湖 241001

【摘要】 目的:用已知的达峰时间(tpeak)和消除速率常数(ke)建立诺模法,估算口服给药的吸收速率常数(Ka)。方法:根据口服给药的血药浓度-时间曲线曲线方程和tpeak、ka和ke的函数关系,进行数学推导建立诺模图。应用诺模图分析46个药物的ka与数学解析法计算的ka,比较评价诺模图的准确度。用高效液相色谱荧光法检测18位健康志愿者羧甲司坦的血药浓度,将羧甲司坦实测血药浓度与由ka结合其他药代动力学参数的估计血药浓度比较,评估诺模图执行误差。结果:诺模图估算的ka值与解析法计算的ka值接近;MDPE和MDAPE执行误差分别为1.32%,18.15%。结论:本文设计的诺模图准确可靠,执行误差符合临床药代动力学要求。可为制定合理的个体化给药方案提供一个方便快捷的方法。

【Abstract】 OBJEIVE A simple nomogram was construed to estimate the absorption rate coefficient (Ka) using the peak time (tpeak) and the elimination rate coefficient (ke) of drugs administered orally. METHOD The nomogram was based on the plasma concentration-time curve and the funion relation between tpeak,ka and ke. A mathematical analysis was presented which allowed for the construion of single chart nomogram. To check on the degree of accuracy of the developed nomogram. It was used to analyze retrospeive profiles of 46 drugs and compared the ka alues from nomogram and those calculated by solving the equation. To analyze the performance error, the measured carbocisteine concentrations were compared with the predied concentrations by ka from the nomograms along with the other pharmacokinetic parameters. RESULTS The estimations of ka values from nomogram were in very close proximity with the numerical values. The performance error was as follow MDPE and MDAPE are 1.3% and 18.2%, respeively. CONCLUSION The developed nomogram is accurate and reliable. The sive of performance error meets the demand of clinical pharmacokinetics. The nomograms may offer another convenient and easy method for rational individualized dosage regimen.

  • 【文献出处】 中国临床药理学杂志 ,The Chinese Journal of Clinical Pharmacology , 编辑部邮箱 ,2003年03期
  • 【分类号】R96
  • 【下载频次】178
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