【摘要】 目的 探讨垂体后叶素联合血管扩张剂(消心痛)治疗门脉高压症合并上消化道大出血患者时,对其血液动力学的影响。方法 我院1998-2002年收治的门脉高压上消化道大出血患者共80例,分为两组。垂体后叶素组(n=40)依常规应用垂体后叶素治疗;联合组(n=40)为垂体后叶素加血管扩张剂(消心痛)方案治疗。观察治疗前、后24h的门静脉系统和全身血液动力学的变化情况、总体疗效和药物不良反应。结果 与垂体后叶素组相比,联合组的门静脉血液动力学指标下降和CVP上升较明显,但无统计学意义(P>0.05),心率下降及平均动脉压上升的幅度和药物不良反应发生率有明显的差异(P<0.05),总体有效率也明显提高(P<0.05)。结论 垂体后叶素联合消心痛对门脉高压上消化道大出血的治疗有明显的优越性。更多还原

【Abstract】 Objective To investigate the effects of Vasopressin(VP) and vasodilate on the portal and systematic hemodynamics in treatment of upper digestive tract hemorrhage due to portal hypertension(PH). Methods From 1998 to 2002, we detected 80 patients with upper digestive tract hemorrhage due to PH, who were divided randomly into 2 groups (n=40). The VP group was treated with VP, and the Combination group was subjected to VP plus vasodilate. The change of portal and systematic hemodynamics before and 24h after therapy, the rates of efficacy and side-effects were analyzed. Results Compared with VP group, the changes of portal hemodynamics and CVP were no significant difference(P>0. 05), the change of HR and MAP, and the rate of efficiency and side-effects showed statistical difference (P<0. 05). Conclusions The combination of VP and vasodilate is dominate to VP lonely in the treatment of digestive tract hemorrhage due to PH.更多还原