【摘要】 目的　研究抑癌基因PTEN在食管癌组织的表达 ,探讨PTEN与食管癌发生发展之间的关系。方法　应用免疫组织化学SABC法对食管癌及癌旁食管粘膜PTEN的表达进行检测。结果　PTEN在食管鳞癌 (4 8 2 2 % )中的表达率明显低于癌旁正常食管粘膜组织 (90 6 3% ) ,有显著性差异 (P <0 0 1)。而且从食管鳞癌Ⅰ至Ⅲ级PTEN表达率逐渐降低 ,鳞癌Ⅰ至Ⅲ级PTEN的表达率分别是 :78 5 7%、 6 0 0 %、 2 7 2 7% ,有显著性差异 (P <0 0 1)。结论　从癌旁正常食管鳞状上皮组织 ,到Ⅰ～Ⅲ级食管鳞癌组织的PTEN表达依次降低 ,表明PTEN在食管癌的发生以及进展过程中有表达缺失。更多还原

【Abstract】 Objective To investigate the expression of the tumor suppressor gene PTEN in esophageal squamous cell carcinomas and the relationship between PTEN and the progression of esophagus cancer. Method The SABC immunohistochemical method was employed to detect the expression of PTEN in paraffin-embedded tissues of esophageal squamous cell carcinoma. The relationship between the gene expression and the clinicopathological features was analyzed. Result PTEN expression of normal pericarcinomatous tissues (90.63%) was significantly higher than that of esophageal carcinoma cases (48.22%). Of the cancer cases, the expression of PTEN showed a close correlation with the pathological stage, decreasing gradually from GradeⅠ(78.57%) to GradeⅡ(60.0%)and GradeⅢ(27.27%),with significant differences. Conclusion There may be a loss of the expression of PTEN in the carcinogenesis and progression of oesophagus carcinoma.更多还原