【摘要】 目的 :探讨低分子右旋糖酐加速尿对肾病综合征 (NS)患者利尿作用与高凝状态的影响。方法 :用随机对照的方法 ,对新入院的住院NS患者使用低分子右旋糖酐加速尿治疗 ,观察其治疗前后的尿量、体重 ,并测定其治疗前后血流变学指标 ,血小板聚集功能、纤溶活性等指标。结果 :NS患者经用低分子右旋糖酐加速尿治疗后较治疗前尿量明显增加 ,体重明显下降 (P <0 .0 1) ,治疗后观察组的尿量、体重与对照组比较差异也有显著性 (P <0 .0 5 )。观察组血浆粘度、全血粘度(高切、低切 )、血栓形成系数、血小板聚集治疗后较治疗前明显好转 (P <0 .0 1) ;对照组治疗前后这些指标无明显变化 (P >0 .0 5 ) ;治疗后观察组与对照组比较差异有显著性 (P <0 .0 5 ,0 .0 1)。组织纤溶酶原激活物 (t PA)、纤溶酶原活化剂抑制物(PAI)、血浆α2 抗纤溶酶 (α2 AP)治疗前后无明显变化 ,与对照组相比差异无显著性 (P >0 .0 5 )。结论 :使用低分子右旋糖酐和速尿联合治疗NS水肿 ,既可达到利尿消肿的目的 ,又有抗凝、降低高凝状态的作用更多还原

【Abstract】 Objective:To observe the effect of low molecular weight dextran plus furosemide on diuresis and hypercoagulability in primary nephrotic syndrome(PNS).Methods:Forty patients with PNS were treated with low molecular weight dextran plus furosemide in addition to conventional therapy,and their 24 hour urine volume,body weight,hemorheology,platelet aggregation and fibrinolytic indexes (t PA,PAI and α 2 AP) were also determined.Control group ( n= 56) accepted conventional therapy.Results:There were obvious increase of 24 hour urine volume and significant decrease of body weight in control( P< 0.05) and treatment group( P< 0.01) after therapy.Hemorheology and platelet aggregation showed dramatic improvement in treatment group( P< 0.01) but not in control group ( P> 0.05) after therapy.There were no statistical differences in fibrolytic indexes between two groups ( P> 0.05).Conclusion:Combined therapy of low molecular weight dextran and furosemide in PNS not only has diuretic action,but also has anticoagulant effect. [更多还原