【摘要】 合成了 4个天然 1 ,7-二芳基庚烷类化合物 :1 -(4′-羟基 -3′-甲氧基苯基 ) -7-(4″-羟基苯基 ) -5 -羟基 -3-庚酮 (1 ) ,1 -(4′-羟基 -3′-甲氧基苯基 ) -7-(4″-羟基苯基 ) -4 -庚烯 -3-酮 (2 ) ,1 -(3′,4′-二羟基苯基 ) -7-(4″-羟基苯基 ) -5 -羟基 -3-庚酮 (3) ,1 -(3′,4′-二羟基苯基 ) -7-(4″-羟基苯基 ) -4 -庚烯 -3-酮 (4 ) .化合物 1 ,2 ,4为首次合成 .更多还原

【Abstract】 Diarylheptanoids constitute a distinct group of metabolites of natural plant characterized by two aromatic rings linked by a linear seven aliphatic chain. There have been few reports on the biological activities of diarylheptanoids, most of which appearing in the areas of anti-inflammatory, anti-oxidative, superoxide scavenging and anti-hepatotoxic effects. Some of them are used as traditional medicine in Asia. Compounds 1 and 2 were firstly isolated from the rhizomes of Zingiber offical respectively. 1-(3′,4′-Dihydroxyphenyl)-7-(4″-hydroxyphenyl)-4-hepten-3-one(4) was firstly isolated from the flowers of A. japonica. Herein, we report the synthesis of these four natural 1,7-diarylheptanoids, 5-hydroxy-1-(4′-hydroxy-3′-methoxyphenyl)-7-(4″-hydroxyphenyl)-3-heptanone (1), 1-(4′-hydroxy-3′-methoxyphenyl)-7-(4″-hydroxyphenyl)hept-4-en-3-one (2)(Gingerenone C), 5-hydroxy-1-(3′,4′-dihydroxyphenyl)-7-(4″-hydroxyphenyl)-3-heptanone (3) and 1-(3′,4′-dihydroxyphenyl)-7-(4″-hydroxyphenyl)hept-4-en-3-one (4). And compounds 1, 2 and 4 were firstly synthesized.更多还原