【摘要】 <正> 在模拟蛋白质的分子识别功能方面,人工合成以氨基酸为主要结构单元的环肽由于更接近于生命物质,因此作为主体分子来模拟生命现象更贴切。目前,这方面的研究主要集中在环肽对碱金属、碱土金属以及磷酸酯的识别或跨膜传输等方面。环肽通过骨架或侧臂与过渡金属离子的配位研究也仅有几例。实际上,许多过渡金属,如Cu(Ⅱ),Zn(Ⅱ)和Fe(Ⅱ)等在稳定蛋白质的构象及增强更多还原

【Abstract】 A 26-membered nicotinoyl disubstituted cyclopseudopeptide was synthesized through a simple six-step prvcedure(Scheme 1) with cystine dimethyl ester, iminodiacetic acid, and nicotinoyl chloride hy-drochloride as the starting materials. The structure of the key intermediates 4 and 5 was verified by 1H NMR and FAB-MS, and that of the final product 7 by ’H NMR, IR, FAB-MS and elemental analysis. Subsequent treatment of 7 with Cu(ClO4)z gives a mononuclear cuprate(Ⅱ ) complex whose structure was characterized by IR, FAB-MS. The quick formation of the cuprate-cyclopeptide complex demonstrates that the title peptide can serve as a good reception in Cu( Ⅱ ) recognition.更多还原