【摘要】 用数学模型法研究了细胞间液中 Gd( )对 Ca( )物种的影响 ,并利用人工神经网络方法估算配合物稳定常数 .结果表明 ,细胞间液中 Ca( )物种分布受 Gd( )总浓度变化的影响 .当 Gd( )总浓度为其在细胞间液中的本底浓度时 ,Ca( )主要以自由 Ca( )离子 ( 71 .0 % ) ,[Ca( HCO3) ]( 9.5 % )和 [Ca( Lac) ]( 6.0 % )等物种存在 .随着 Gd( )浓度的提高 ,Gd( )主要与 Ca( )竞争磷酸根及碳酸根 ,并有竞争生物小分子配体趋势 ,从而导致 Ca( )物种随 Gd( )浓度变化重新分布更多还原

【Abstract】 The effect of Gd(Ⅲ) on Ca(Ⅱ) species in human interstitial fluid was studied by mathematical model method. Meantime artificial neural network was applied to the estimation of lg β value of some complex. The results show that the variety of concentration of Gd(Ⅲ) has effect on Ca(Ⅱ) species. At the background the concentration of Gd(Ⅲ) in human interstitial fluid, Ca 2+ (71.0%), [Ca(HCO 3)](9.5 %) and (6.0%) are main species. With the concentration of Gd(Ⅲ) rising, Gd(Ⅲ) firstly competes with Ca(Ⅱ) for PO 3- 4 and CO 2- 3, then tends to compete for other biological low molecular weight ligands. This leads to Ca(Ⅱ) redistribution with the variety of concentration of Gd(Ⅲ).更多还原