【摘要】 通过静电液滴发生器制备海藻酸钙凝胶微球 ,通过理论推导得到了微球粒径的计算公式 .理论计算的结果表明 ,凝胶微球粒径的大小取决于静电压、电极距离、针头内径大小、注射器流速、海藻酸钠粘度和表面张力以及凝胶化体积收缩系数 .理论计算结果与实验结果吻合得相当好更多还原

【Abstract】 Gel microspheres of calcium alginate and alginate-polycation microcapsules are widely used as the mobilization of biology, controlled release of drug and biologic adsorbents. In this paper, gel microspheres of calcium alginate are prepared through electrostatic droplet generator and formula of theoretical calculation of diameter of gel microspheres is accordingly given under different conditions. The results of theoretical calculation show that diameter of gel microspheres is determined by the voltage, distance between positive pole and negative pole, inner diameter of needle, flow rates of syringe pump and physicochemical properties of alginate. The diameter of gel microspheres will decrease with increasing voltage and decreasing the distance between electrode and it has the lowest value, which is defined as the critical diameter of gel microspheres and is in a direct proportion to the inner diameter of needle. The uniform gel microspheres with different diameters are prepared through changing physicochemical properties of alginate and parameters of electrostatic droplet generator. In order to obtain good spherical and homogeneous beads, the optimum mass concentration range of sodium alginate is from 0.15 to 0.20 g/L. The experimental results match the theoretical calculation well. The formula of theoretical calculation can be widely used to study the effect of physicochemical properties of alginate and parameters of electrostatic droplet generator on the diameter of gel microspheres of calcium alginate.更多还原