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β-K4H3[SiW9O37（CpTi）3]·11H2O环戊二烯钛多酸衍生物与DNA作用研究
Investigation on the Interaction of β-K4H3 [SiW9O37（CpTi）3]·11H2O Polyacid Derivative with DNA
【Abstract】 The interaction between β-K 4H 3 [SiW 9O 37(CpTi) 3]·11H 2O and DNA was investigated by agarose gel electrophoresis. The results suggest that β-K 4H 3[SiW 9O 37(CpTi) 3]·11H 2O can degrade the genomic DNA. The treatment of plasmid DNA with β-K 4H 3 [SiW 9O 37(CpTi) 3]·11H 2O resulted in a fast moving band in front of the three normal conformations(super coiled DNA, linear DNA and relaxed circular DNA) in agarose gel electrophoresis . These results indicate that this chemical material may have the ability to specifically cleavage DNA or to alter conformation of DNA molecules.
【关键词】 β-K4H3[SiW9O37(CpTi)3]·11H2O；
琼脂糖凝胶电泳；
DNA；
【Key words】 K 4H 3 [SiW 9O 37(CpTi) 3]·11H 2O； Agarose gel electrophoresis； DNA；
【Key words】 K 4H 3 [SiW 9O 37(CpTi) 3]·11H 2O； Agarose gel electrophoresis； DNA；
【基金】 国家自然科学基金 (批准号 :39970 82 4)资助
- 【文献出处】 高等学校化学学报 ,Chemical Research In Chinese Universities , 编辑部邮箱 ,2003年02期
- 【分类号】R73-36
- 【被引频次】8
- 【下载频次】98