【摘要】 研究了辛可尼定(cinchonidine)作手性修饰剂修饰的氧化铝负载铂纳米簇合物(Pt-PVP-γ-Al2O3)催化丙酮酸甲酯不对称氢化反应,采用甲醇的碱溶液做溶剂,着重考察了低温条件下催化剂的活性和对映选择性的变化.优化的反应条件为0℃,5.0MPaH2,[cinchonidine]=3.24×10-3mol/L,[KOH]=0.02mol/L,1h内丙酮酸甲酯不对称加氢的转化率为32.2%,对映选择性达到52.2%;更多还原

【Abstract】 The enantioselective hydrogenation of methyl pyruvate in the presence of γ-Al₂O₃ Supported Platinum Nanoclusters and chiral modifier cinchonidine was investigated. The results show that cinchonidine as a chiral modifier not only induce the enantioselectivity but also greatly accelerate the reaction rate. The effects of concentration of KOH and cinchonidine in MeOH, temperature, hydrogen pressure, reaction time on the asymmetric hydrogenation of methyl pyruvate have been studied. Under the optimum conditions of 0 ℃, 5.0 MPa H₂ and 3.24×10^-3 mol/L of cinchonidine concentration in KOH/MeOH（0.02 mol/L） solution for 1 h, the conversion of methyl pyruvate and the e.e. value of product are 32.2% and （52.5%）, respectively.更多还原