【摘要】 利用脉冲辐解技术研究了二硫化碳(CS2)被氧化生成的阳离子自由基,以时间分辨瞬态吸收光谱方法获取CS2阳离子自由基的特征吸收谱。同时,研究了CS2阳离子自由基损伤生物靶分子的机理,测定了相关的反应动力学常数。结果发现,CS2阳离子自由基能与DNA、dGMP、酪氨酸和色氨酸反应产生新的产物,在CS2对生物靶分子的氧化损伤中可能起着重要的作用。更多还原

【Abstract】 Pulse radiolysis technique was used to probe the generation of radical cations from carbon disulfide, and characteristic absorbance spectra of the radical cations were obtained by time-resolved transient absorbance spectrum method. The injury mechanism of the bio-molecular targets by the free radicals and relative constants of reaction kinetics were studied. Results showed that the radical cations could react with DNA, dGMP, tyrosine and tryptophan and form new products, which may play an important role in oxidative injury on bio-molecules by carbon disulfide.更多还原