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三(对溴苯甲酰基)纤维素的合成及其分离性能的考察
Synthesis and the Chiral Separation Ability of Cellulose Tris (4- bromobenzoate)
【摘要】 采用超声方法合成了三(对溴苯甲酰基)纤维素[CTBB],并用红外光谱、元素分析对此衍生物的结构进行了表征。将等量微晶纤维素(MC)与三(对溴苯甲酰基)纤维素混合制成一种新型的手性薄层板。结合展开剂系统的优化,6种手性药物对映体获得了良好的分离,分离因子α≥1.30。此固定相适用于正相和反相液相色谱。
【Abstract】 Cellulose tris (4-bromobenzoate) (CTBB) was ultrasonic-ally prepared and characterized by infrared speclrometry and element analysis. The mixture of CTBB and microcrystalline cellulose (1 : 1 W/W) was used as chiral stationary phase (CSP) of thin-layer chromatography. Optimized of mobile phases, six chiral drags were separated completely on the CSP, such as hexane-ethanol, hexane-2-propanol, hexane-2-propanol 1% triethylarnine acetic acid (TEAA) acetonitrile-1 % TEAA acetonitrile-water, and the separation factors(α) are more than 1 .30. The results showed that this CSP was stable and suitable to both normal phase and reversed phase chromatography.
【Key words】 Cellulose tris(4-bromobenzoate)； chiral stationary phase； chiral drugs； thin-layer chromalography；
- 【文献出处】 分析化学 ,Chinese Journal of Analytical Chemistry , 编辑部邮箱 ,2003年05期
- 【分类号】O657.7
- 【被引频次】5
- 【下载频次】133