【摘要】 舒乐安定在0.1 mol/L NH3-NH4Cl缓冲溶液(pH 9.40)中,用线性扫描伏安法,在Pt/GC离子注入修饰电极上,形成一良好的线性扫描伏安还原峰,峰电位Ep=-0.70V(vs.SCE)。其峰电流与舒乐安定浓度在3.0×10-9-1×107和1×10-7-1.5×10-6mol/L范围内呈线性关系,相关系数均为0.9999,检出限为3.0×10-9mol/L。并用于片剂的测定,回收率在96.5％～98.5％之间,结果是可靠的。用循环伏安法研究了体系的性质。实验表明,电极过程为不可逆吸附。用AES、XPS和SEM等表面分析方法证明,Pt离子确实注入到玻碳基体电极表面,Pt以原子态存在,催化了舒乐安定的还原。更多还原

【Abstract】 In 0.1 mol/L NH3-NH4C1 buffer solution (pH 9.4) , a well voltammetric reduction peak of estazolam was observed by linear sweep voltammetry at Pt/glassy carbon (Pt/GC) ion implantation modified electrode. The peak potential is -0.70V (vs.SCE) . The peak current is proportional to the concentration of estazolam over the range of 3 .0 × 10-9 - 1.0 × 10-7 and 1.0 ×10-7 - 1.5 × 10-6 mol/L with a detection limit of 3 .0 × 10-9 mol/L. This method can be applied successfully for the determination of trace estazolam. The electrochemical behavior of the system was also studied by cyclic voltammetry, and the experiment results showed that the electrode process was irreversible with adsorption. The element composition, atomicity form and depth of distribution at the surface of Pt/GC electrode were determined by Auger electron spectroscopy, X-ray photoelectron spectroscopy and scannig electron microscope. The catalysis behavior and reaction mechanism of Pt/GC modified electrode were also studied.更多还原