【摘要】 目的 :探讨慢性肾炎患者血清白介素 - 2 (IL - 2 )、白介素 (IL - 6 )、肿瘤坏死因子 (TNF -α)在肾炎发生、发展过程中的浓度变化及相互关系。方法 :用放射免疫分析检测 71例慢性肾炎患者及 36例年龄和性别相匹配的健康志愿者血清IL - 2、IL - 6、TNF -α的水平。结果 :①慢性肾炎患者外周血中IL - 6、TNF -α水平明显高于正常对照组 (p <0 0 1 ) ,而IL - 2水平明显低于正常对照 (p <0 0 1 ) ;②直线相关分析显示 :IL -6、TNF -α与BUN呈正相关 (p <0 0 1 ) ;③各临床分型组间细胞因子浓度水平比较无显著性差异。 结论 :细胞因子IL - 2、IL - 6、TNF -α在慢性肾炎的发生、发展过程中相互作用 ,观察其浓度变化对探讨发病机理、预防及指导用药均有重要价值。更多还原

【Abstract】 Objective To investigate the changes of serum IL-2, IL-6 and TNF-α levels in patients with chronic glomerulonepritis of various types and stages. Methods Serum IL-2, IL-6 and TNF-α levels were measured with RIA in 71 patients with chronic glomerulonephritis and 36 controls. Results ①Serum levels of IL-6 and TNF-α were significantly higher in patients with chronic glomerulonephritis than those in controls ( p <0 01) but serum IL-2 levels were significantly lower in the patients ( p <0 01). ②Serum IL-6 and TNF-α levels were positively correlated to BUN levels ( p <0 01). ③There were no significant differences of these cytokines levels among the different types of patients (i.e. general type n=18, nephrotic type n=33 and hypertensive type n=20). Conclusion These cytokines participated in the pathogenesis of chroric glomerulonephritis. Monitoring the changes of their serum levels was helpful for the management of the disease.更多还原