【摘要】 以氯苯那敏和 β$C环糊精为研究对象 ,利用电化学方法测定了它们相互作用形成超分子化合物的结合常数。实验考察了氯苯那敏在不同pH的Na2 HPO4 介质中的伏安行为 ,发现吸附还原峰电流和峰电位随pH的不同而发生变化 ,证明H+ 离子参加了氯苯那敏的电极反应 ,并且pH为 4 .4 7时 ,氯苯那敏在 - 1 .337V有较敏锐的吸附还原波。利用β$C环糊精结合氯苯那敏后 ,其表观扩散系数的变化引起还原峰电流改变的原理 ,采用线性扫描伏安法研究了氯苯那敏与β$C环糊精的相互作用 ,测得它们的结合常数为 2 .83× 1 0 2 mol- 1·L。这为进一步研究药物分子与受体相互作用的电化学研究建立了基础更多还原

【Abstract】 Electrochemical characterization of chlorpheniramine and its interaction with β-Cyclodextrins in Na 2HPO 4 buffer solutions with different pH values were studied with linear sweep voltammetry. The electrochemical results indicate that absorptive peak currency ( i p ) is changed in buffer solution with different pH values, which illuminates that the reduction of Chlorpheniraminc on the electrode is related to H +. Clorpheniramine gives a sensitive adsorbtive peak at -1.337 V (vs. SCE), when pH is 4.47. The interaction of β-cyclodextrin and chlorpheniramine was also studied. The inclusion constant is determined as 2.83×10 2 mol -1 ·L.更多还原