【摘要】 目的　探讨超氧化物歧化酶模型化合物 (m odel of superoxide dism utase,MSOD) (Cu2 C2 1 N1 4H2 7Cl1 3)作用于正常口腔颊黏膜细胞的安全剂量范围。方法　用单细胞凝胶电泳法 ,通过观察 Tail Mom ent和Tail DNA %这两项指标的变化情况检测染毒后口腔颊黏膜细胞的 DNA损伤情况。结果　测试结果表明 2 5、5 0、1 0 0μg/ m l MSOD处理组相互之间、与阴性对照组之间均无显著性差异 ,但与阳性对照组之间有极显著性差异。结论　当 MSOD浓度 <1 0 0μg/ ml时 ,没有发现 MSOD对口腔颊黏膜细胞 DNA的明显损伤作用更多还原

【Abstract】 Objective To explore the safe range of the model of superoxide dismutase (MSOD)on normal buccal cells. Methods Using comets’ tail moment and tail DNA% as parameter to detect the DNA migration of buccal cell by single cell gel electrophoresis(SCGE). Results The results show that there is no significant difference between MSOD group and control group, but the difference between MSOD and H 2O 2 is extremely significant. Conclusions MSOD doesnot cause DNA damage of human buccal cells if the concentration is below 100 μg/ml. [更多还原