【摘要】 目的　探讨氟、硒、镉对大鼠体内脂质过氧化物 (LPO)含量及谷胱甘肽过氧化物酶 (GSH—Px)活性的影响。方法　采用饮水给毒亚急性动物毒理实验 ,测定其血清、肝、肾及睾丸中LPO、GSH—Px的含量。结果　过量氟、硒、镉可诱导大鼠血清、肝组织中LPO含量显著增加 ,GSH—Px活性显著降低。氟、镉对肾脏和睾丸具有同样的作用 ,而硒则不明显。氟、硒、镉任意二者联合实验组较氟硒镉分别实验组LPO含量显著降低 ,GSH—Px水平显著增高 ,氟、硒、镉三联实验组较二联实验组的这种作用更强 ,其LPO、GSH—Px的含量与对照组接近。结论　提示过量的氟、硒、镉均可促进动物体内脂质过氧化作用增强 ,并抑制GSH—Px的活性 ,使机体抗氧化能力降低。但当氟硒镉任意二种或三种元素共存时 ,表现为相互拮抗作用 ,从而减轻或消除对机体的损害作用更多还原

【Abstract】 Objective To explore the influence of Fluorine(F), Selenium(Se) and Cadmium(Cd) on the level of LPO and activity of GSP-Px in rats. Methods Subacute toxicological experiments-drinking poison in rats was used and the content of GSP-Px and LPO in rats’ serum, liver, kidneys and testicles was measured. Results Excessive F, Se or Cd could lead to a significant increase of LPO content in rats’ serum and liver with a significant decrease of GSH-Px activity. Se didn’t have the obvious effect on kidneys and testicle which F and Cd had. Significant LPO decrease of LPO content and increase of GSH-Px activity in any random-selection-of-two-elements group was found compared with any random-selection-of-one-element group, the effect was more significant in F, Se and Cd group whose LPO GSG-Px content was close to the control group than a random-selection-of-two group. Conclusion Excessive F, Se or Cd could enhance lipid peroxidating, restrain GSH-Px activity and decrease anti-oxidation ability in animals. The harmful effect was decreased or eliminated when any random-selection-of-two-elements or the three elements co-exist because of counteraction.更多还原