【摘要】 【目的】　观察窒息后胰岛素样生长因子 1(IGF 1)、降钙素基因相关肽 (CGRP)含量变化 ,分析其与窒息后病理生理及脑损伤的关系 ,探讨二者对脑损伤的保护作用。　【方法】　用放射免疫法测定血IGF 1、CGRP含量。　【结果】　①第一天 ( 1d)窒息儿IGF 1含量降低 ,重度、轻度与对照组比较F =11.2 64 ,P <0 .0 0 1;CGRP升高F =11.180 ,P <0 .0 0 1。第七天 ( 7d)时IGF 1、CGRP含量接近对照组 ,重度组IGF 1仍低于轻度组 ;1dHIE患儿IGF 1含量低于单纯窒息儿 ,CGRP含量高于单纯窒息儿 ,7dIGF 1低于单纯窒息儿。②HIE患儿 1d轻、中、重三组IGF 1含量依次降低 ,均低于对照组 ,而CGRP依次增高。 7d轻、中、重三组IGF 1都上升 ,重度组仍低于对照组。③HIE患儿 1d有蛛网膜下腔出血者CGRP含量高于无出血组。④窒息儿及HIE患儿 1dIGF 1与CGRP呈直线负相关。　【结论】　①IGF 1、CGRP参与了新生儿窒息病理生理过程 ,与脑损伤病理机制密切相关 ;②CGRP在蛛网膜下腔出血中发挥作用 ;③窒息及HIE患儿早期IGF 1与CGRP呈负相关更多还原

【Abstract】 To explore the effect of two factors for brain damage after asphyxia, analyze the changes of pathophysiological and relation to brain damage. IGF 1 and CGRP levels in peripheral blood were determined by using radioimmunoassay. ① IGF 1 levels among severe asphyxia, slight asphyxia and normal neonates at 1 day were different significantly ( F=11.180,P <0.001). IGF 1 and CGRP levels at 7 days were closed to group of normal neonates and compared to that at 1 day there were significantly different, but IGF 1 was lower in severe than in slight. ② Levels of IGF 1 among mild, moderate and severe HIE decreased gradually, and all were lower than pure asphyxia group, but CGRP rose and were higher than group of normal neonates at 1 day. All that IGF 1 rose and CGRP decreased at 7 days compared to levels at 1 day were significantly different, while IGF 1 was lower than group of normal neonates in severe HIE at 7 days. ③ CGRP levels was higher for neonates with subarachnoid haemorrhage at 1 day. ④ Linear correlation showed IGF 1 negatively correlated with CGRP in neonatal asphyxia and HIE at 1 day. [Conclusions] ①IGF 1 and CGRP influenced the pathophysiological processes of neonatal asphyxia, they were closely related to pathogenestic mechanism of brain damage, protected nerve system. ② CGRP played a role in subarachnoid haemorrhage.更多还原