【摘要】 【目的】　探讨小剂量叶酸片 (斯利安 )对神经管畸形 (NTDs)再发生的预防效果。　【方法】　 2 2 9例有NTDs妊娠史的已婚育龄妇女作为观察组 ,从孕前 3个月开始口服斯利安 ,直至妊娠满 3个月。对照组为有NTDs妊娠史 ,但妊娠前后从未服用斯利安。比较观察组与对照组NTDs再发生率。　【结果】　观察组有 8例再次发生NTDs,再发生率为 3 .0 0 %;对照组有 9例发生NTDs ,再发生率为 14 .0 0 %。NTDs再发生率观察组明显低于对照组 ,两者相比 ,差异有非常显著性 (P <0 .0 1)。　【结论】　斯利安预防NTDs再发生有非常显著的效果。更多还原

【Abstract】 To investigate the effects of folic acid on the prevention of recurrent fetal neural tube defects(NTDs). 229 women with a history of fetal NTDs assigned as monitoring group began to take 0.4～0.8 mg folic acid every day at least three months until the end of the first trimester. 69 women with a history of fetal NTD who did not intake any folic acid before or during the pregnancy were assigned as control group.The rate of fetal NTDs recurrence was compared. The rate of fetal NTDs recurrence in the monitoring groups(3.00%) was much lower than that of control group(14.00%).There was extramely significant difference between two groups. [Conclusion] Folic acid is really effective in the prevention of fetal NTDs recurrence.更多还原