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硫酸镁联合纳洛酮治疗新生儿缺氧缺血性脑病疗效观察

To observe the curative effect of magnesium sulfate and naloxone in treating the newborn infant suffering hypoxic-ischemic encephalopathy

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【作者】 阮仙利梁国安芦洪萍

【Author】 RUAN Xian - li,LIANG Guo - an,LU Hong - ping (Taizhou Hospital Affiliated Wenzhou Medical College,Zhejiang Linhai317000,China)

【机构】 浙江省温州医学院附属台州医院浙江省温州医学院附属台州医院 浙江临海317000浙江临海317000浙江临海317000

【摘要】 目的:探讨硫酸镁联合纳洛酮对新生儿缺氧缺血性脑病(HIE)的治疗作用。方法:观察治疗前后观察组与对照组临床疗效、脑CT的恢复、NBNA评分以评价疗效。结果:治疗后观察组与对照组比较,在临床疗效(χ2=4.73,P<0.05)、脑CT恢复(中度HIEχ2=5.56,P<0.05;重度HIEχ2=6.82,P<0.01)、NBNA评分结果(中度HIEχ2=6.68,P<0.01;重度HIEχ2=5.24,P<0.05)均明显优于对照组。结论:硫酸镁联合纳洛酮治疗HIE有明显疗效。

【Abstract】 Objective:To observe the curative effect of magnesium sulfate and naloxone in treating the newborn infant with hypoxic-is-chemic encephalopathy.Methods:To observe the treatment group and the control group and evaluate their clinic curative effects,recov-ery of brain CT and NBNA in the pro and post-treatment.Result:After treatment,the results of clinic curative effect(χ 2 =4.73,P<0.05),recovery of brain CT(middle degree HIE group,χ 2 =5.56,P<0.05;severe degree HIE group,χ 2 =6.82,P<0.01)and NBNA on treatment group(middle degree HIE group,χ 2 =6.68,P<0.01;severe degree HIE group,χ 2 =5.24,P<0.05)are obviously better than those of control group.Conclusion:Magnesium sulfate and naloxone have obvious effects in treating HIE.

  • 【文献出处】 儿科药学杂志 ,Journal of Pediatric Pharmacy , 编辑部邮箱 ,2003年04期
  • 【分类号】R722.1
  • 【被引频次】2
  • 【下载频次】28
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