【摘要】 目的:探索鼻咽上皮Epstein-Barr virus(EBV)基因检测对鼻咽癌的诊断价值。方法:132例患者用鼻咽刷刷取鼻咽上皮细胞采用单盲PCR法测定EBV-DNA。全组病例按病理检查结果分为鼻咽癌组(68例),非鼻咽癌组(64例)。结果:68例鼻咽癌EBV-DNA阳性率94.12％。64例非鼻咽癌EBV-DNA阳性率12.5％(P<0.005)。结论:鼻咽上皮EBV-DNA的检测对鼻咽癌的诊断有较高敏感性和特异性。更多还原

【Abstract】 Objective: To evaluate value of the examination of EBV-DNA in the cells of nasopharyngeal mucous biopsy for early deagnosis of nasopharyngeal carcinoma. Methods-The examination of EBV-DNA was determined by the assay of PCR in 68 patients with nasopharyngeal carcinoma (50 males and 18 females,ranging in age from 22 to 75 years old)and 64 control group (41 males and 23 females,ranging in age from 15 to 68 years old). The positive result was using of single-blind analysis. Result: The positive rate of EBV-DNA was 94.12% in the group of nasopharyngeal carcinoma and 12- 5% in the control group ( P <0. 005). Conclusion:The axamination of EBV-DNA in the cells of nasopharyngeal brush biopsy could be a higher sensitive and specific way for early diagnosis on patients with nasopharyngeal carcinoma.更多还原