【摘要】 目的　检测低顺应性膀胱组织中Ⅰ型、Ⅲ型胶原蛋白基因表达。方法　用原位杂交的方法检测大鼠梗阻性低顺应性膀胱组织中Ⅰ型、Ⅲ型胶原蛋白mRNA表达的改变。结果　与正常对照组相比 ,低顺应性膀胱组肌层内Ⅰ型、Ⅲ型胶原蛋白基因表达被上调 ,且Ⅲ型胶原蛋白基因表达被上调的程度更为显著。结论　在大鼠的梗阻性低顺应性膀胱中 ,发现膀胱组织肌层内Ⅰ型、Ⅲ型胶原蛋白基因表达被上调 ,而这两种基因表达的上调与梗阻后低顺应性膀胱的形成存在一定的关系更多还原

【Abstract】 Objective To detect the gene expressions of collagen types Ⅰ and Ⅲ in obstructive low compliant bladder in rats. Methods The expressions of collagen types Ⅰ and Ⅲ mRNA in rat bladder tissues were detected by in situ hybridization. Results Compared with those in the normal control, the gene expressions of collagen types Ⅰ and Ⅲ in smooth muscle of low compliant bladder were up regulated. Type Ⅲ gene expression was more obvious than type Ⅰ. Conclusion The expressions of collagen types Ⅲ and Ⅰ in obstructive low compliant bladder in rats are up regulated, which is related with low compliant bladder after obstruction.更多还原