【摘要】 目的　研究恒河猴前额叶执行控制的行为和电生理特点。方法　 3只恒河猴用于行为研究 ,其中 2只恒河猴执行视觉分辨的go nogo任务时 ,记录其两侧前额叶皮层神经元电活动 ,用matlab做事后分析。结果　①三只猴执行go nogo任务的反应时分别为 (4 19± 18)ms、(3 76± 2 6)ms和 (5 40± 2 1)ms ;②在 2只猴的前额叶皮层共进行了 41次穿刺 ,记录到 92个任务相关的神经元 ,共分为 5类 :视觉信号相关的神经元 ;决策 (延迟期 )相关的神经元 ;go运动相关的神经元 ;奖励相关的神经元 ;多事件相关的神经元 ;③go反应错误时神经元对go线索的反应低于go反应正确时神经元对go线索的反应 ,nogo反应错误时神经元对nogo线索的反应高于nogo反应正确时神经元对nogo线索的反应 ;正确决策时 ,go决策相关的神经元放电频率显著高于nogo决策相关的神经元放电频率 ,但决策错误时则相反。结论　①前额叶皮层由多种神经元组成 ;②恒河猴执行go nogo任务错误可能有两类 :一类是线索期错误 ,另一类是决策期错误。提示注意和决策是执行控制的核心。更多还原

【Abstract】 Objective To explore the behavioral and electrophysiological characteristics of prefrontal executive control in macaca mulatas. Methods Three macaca mulatas were used for behavioral research. Neuronal activities of the prefrontal cortex were recorded in two monkeys while visual discriminated go/no go tasks were being performed. Results ① The response time was (419±18)ms, (376±26)ms and (540±21)ms in three monkeys while performing go/no go tasks; ② A total of 41 tetrodes penetrations were made in the PFC of two monkeys. A total of 92 task related neurons were sampled and categorized as 5 types: visual signal related neurons, decision making related neurons, go movement related neurons, reward related neurons and multi events related neurons; ③ When it was correct, the discharge rate of a neuron to a go signal was significantly higher than that to a no go signal during cue period; the discharge rate of a decision making neuron in a go task was significantly higher than that in a no go task. However, when it was wrong, the situation was on the contrary during delay period. Conclusions ① The prefrontal cortex contains various kinds of neurons; ② There are two types of errors in executing go/no go tasks: cue period error and delay period error.更多还原