【摘要】 人类端粒酶催化亚单位又称端粒酶逆转录酶 ,为端粒酶激活的限速酶 ,与端粒酶活性表达一致 ,对癌病变特异。一些化疗药物、中药、核酶及反义寡核苷酸均能不同程度地抑制hTERT -mRNA的表达 ,同时抑制了端粒酶活性 ,减慢了肿瘤细胞的生长速度。更多还原

【Abstract】 Human telomerase catalytic subunit (e.g. human telomerase reverse transcriptase, hTERT)which is rate-limiting enzyme of telomerase, is consistent with expression of telomerase activity and specific for tumor?Some chemotherapic remedy, Chinese medicine, ribozyme and antisense oligos can inhibit expression of hTERT-mRNA and telomerase activity , slow the growth of tumor.更多还原