【摘要】 为探讨大骨节病 (KBD)的骨髓病变、疾病本态及其病因 ,在光镜下复查了本所尸检档案 2批共 16例的骨切片 ,结果 15例见炎性充血、15例见纤维素渗出 ,16例见水肿 ;在此背景上 ,少数病例见淋巴细胞或单核巨噬细胞为主的炎细胞浸润、噬血细胞症、小血管纤维素样坏死、血管周套形成、炎性肉芽组织 ,以及笔者另文报告的 14例骨髓血细胞坏死伴核内嗜酸性包涵体形成 (提示病毒感染 )等表明 ,病尸 14 / 16例骨髓内有急性炎症 ,其中部分病变符合 型超敏反应的组织像。包涵体形成是病毒杀细胞性感染的形态学证据。包涵体在骨髓坏死细胞核内的出现强化了某病毒感染与骨髓血细胞坏死间的因果联系 ,骨髓急性炎症的病因可能是某特异病毒感染更多还原

【Abstract】 To probe the lesions in bone marrows in Kaschin Beck disease (KBD), the nature of the disease and its cause, the bone sections of 16 cases (2 batches ) of our own autopsy files were reexamined with light microscope. Inflammatory hyperemia was seen in 15 cases. Fibrin exudation was seen in 15 cases and edema was seen in 16 cases. On the background , there were an inflammatory infiltrations with prominent lymphocytes or monocyte macrophages, hemophagocytosis, fibrinoid necrosis in small blood vessels, perivascular cuffing, inflammatory granulation tissues in some cases, and also blood cell necrosis with intranuclear inclusion body formation (suggesting a viral infection) in the necrotic cells and so on in bone marrows in 14 cases which has been reported in another paper by the author. These results indicated that there were an acute inflammation, parts of them coincided with histologic changes of type Ⅳ hypersensitivity in bone marrows in 14 cases. The formation of inclusion bodies is morphologic evidence of viral cytocidal infection. The fact that inclusion bodies are found in the nuclei of necrotic cells in bone marrows reinforces the etiologic relationship of the viral infection with blood cell necrosis in bone marrows. The cause of acute inflammation in bone marrows might be a specific viral infection.更多还原