【摘要】 据估计,目前全世界感染丙型肝炎病毒(HCV)者约1.7亿。我国大陆以HCV 1b、2a型为多,其中肝细胞癌(HCC)和(或)癌周肝组织HCV抗原阳性率达36.2％(25/69)～72.7％(48/66),这种差异与检测方法的不同有关。HCV感染后通常经由慢性肝炎→肝硬化路径引起HCC。HCV抗原表达与肝细胞恶性转化和肿瘤相关基因的功能改变有关,是HCC发生的重要危险因子之一。更多还原

【Abstract】 It is estimated that there are about 0. 17 billion HCV infection cases worldwide. HCV sub-genotype 1b and 2a have been the most common genotypes found in the mainland China. The positive rate of HCV antigen in hepatocellular carcinoma (HCC)/corresponding non-cancer liver tissues in China is between 36. 2% (25/69)-72. 7% (48/66), which is associated with different detection methods. HCV associated HCC usually occurs along with chronic hepatitis→cirrhosis pathway. There was no doubt a correlation between the expression of HCV antigen and liver cell transformation, and the change of the functions of tumor-associated genes. These results show HCV is an important risk factor for development of HCC.更多还原