【摘要】 目的　分析多发性骨髓瘤肾脏损害的临床特征及其发生的相关因素。方法　对多发性骨髓瘤患者肾脏损害的临床表现及实验室检查进行统计学分析。结果　肾脏损害的发生率为 3 9 1% ( 18/4 6) ,以慢性肾功能不全最常见。骨髓浆细胞数量和尿BJP与肾功能损害之间有显著相关关系 (P <0 0 0 5 ;P <0 0 1) ,贫血及多发性骨损害与肾脏损害有相关关系 (P <0 0 5 )。结论　骨髓浆细胞增殖及尿链蛋白产生可能是多发性骨髓瘤肾脏损害的主要原因更多还原

【Abstract】 Objective To analysis the clinical characteristics and the correlative factor of kidney lesion in multiple myeloma.Methods Analysis of statistics in clinical characteristics and results of laboratory of kidney lesion were carried out in myeloma patients.Results The incidence of kidney lision was 39.1%(18/46),the most common kidney lesion was chromic renal failure.There was a significant correlation between the quantity of bone marrow plasmacyte or urine Bence-Jones protein and renal functional lesion( P <0.005; P <0.001).Anemia or multiple bone lesion was correlated with kidney damaged.Conclusion proliferation of bone marrow plasmacyte and the quantity or urine Benec-Jones protein are main causes of kidney lesion in multiple myeloma.更多还原