【摘要】 目的　分析不孕专科门诊中原发闭经和继发闭经患者中的染色体异常 ,为其生育提供指导。方法　按常规方法制备患者外周血淋巴细胞染色体 ,进行核型分析。结果　在 10 8例病人中共检出染色体异常 2 4例 ,异常检出率为 2 2 2 % ,主要涉及X染色体的数目和结构异常。结论　染色体异常是导致原发和继发闭经的重要原因之一 ,且主要涉及性染色体的异常 ,在对原发闭经和继发闭经患者进行助孕生殖前常规细胞遗传学检查十分必要。更多还原

【Abstract】 Objective To analyze the chromosome abnormalities in the patients with primary and secondary amenorrhea in the infertility clinic, and provide the guidance for their reproduction.Methods Peripheral blood lyphocytes chromoseme samples were prepared and the karyotype was analyzed according to routine method.Results 24 abnormal chromosome karyotypes were detected in 108 cases, the abnormality detection rate was 22.2%, and it was mainly involved in the numerical or structural abnormality of chromosome X. Conclusions Chromosome abnormality is an important cause for primary and secondary amenorrhea, and the X chromosome abnormality is involed mainly.For those patients,chromosome examination should routinely be taken before assistant reproductive technique.更多还原