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黄芪成分F3新制剂抗肿瘤的实验研究

Experimental study on antitumor with astragalus composition F3 new preparation

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【作者】 伦永志李明辉罗学娅刘亚力赵莲华曹利力

【Author】 LUN Yong-zhi, LI Ming-hui, LUO Xue-ya, LIU.Ya-li, ZHAO Lian-hua, CAO Li-li(Medical College of Dalian University, Dalian 116622, China)

【机构】 大连大学医学院大连大学医学院 辽宁 大连116622辽宁 大连116622辽宁 大连116622

【摘要】 [目的]研究黄芪成分F3新制剂对荷瘤小鼠生存期及实体瘤生长抑制的影响。[方法]纯系Balb/c小鼠荷瘤后随机分组,连续用药10d,观察腹水荷瘤小鼠的生存时间;观察抑瘤率的小鼠于荷瘤第15d后处死,剥瘤称重。[结果]腹腔注射黄芪成分F3新制剂能显著延长腹水荷瘤小鼠的生命延长率;对U14、S180实体瘤的抑瘤率分别达71.29%、70.97%。[结论]黄芪成分F3新制剂对荷瘤小鼠具有显著的抑癌作用。

【Abstract】 [Objective] The survival time and the tumor inhibition rate of Astragalus composition F3 new preparation were studied. [Methods] After being inoculated with U14 tumor cells and S180 tumor cells, Inbred male and female Balb/c mice were divided into treated groups and control groups randomly. Drugs were injected for 10 days continuously. The survival time of the mice innoculated with tumor cells was counted. The mice for studying the effect on the tumor inhibition were killed and their tumors were weighed on the 15th day. [Results] The increase in life span of the mice treated by intraperitoneal injection with Astragalus composition F3 new preparation is markedly prolonged, the tumor inhibition rate reaches 71.29% and 70.97% respectively. [Conclusion] Astragalus composition F3 new preparation has significant antitumor effects in the mice innoculated with tumor cells.

【基金】 2000年大连市科技计划项目资助
  • 【文献出处】 大连大学学报 ,Journal of Dalian University , 编辑部邮箱 ,2003年04期
  • 【分类号】R73-36
  • 【被引频次】12
  • 【下载频次】175
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